Research into conolidine has resulted in discovery of an opioid receptor in the human body called ACKR3/CXCR7. ACKR3 is apparently the most desired goal for conolidine, which also disregards the opposite 4 classical opioid receptors(three). Conolidine has become present in the tabernaemontana divaricata plant, that's while in the Apocynaceae https://www.proleviate.com/post/conolidine-an-alternative-natural-pain-relief-to-replace-traditional-painkillers