Hyaluronic injections have questionable gain for pain and performance, and therefore are finest reserved for patients in whom initially-line conservative treatments are already ineffective and who are not candidates for surgery7,8,twenty Opioid analgesics needs to be employed only if conservative pharmacotherapy is ineffective in patients who're not candidates for surgery8 https://www.theorthopaedicandpainpractice.com/non-surgical-treatments-for-knee-joint-pain/